What is the sensitivity of peripheral nerves to injury compared to spinal cord grey matter?

The correct response highlights that peripheral nerves are generally considered to be the least sensitive to injury compared to spinal cord grey matter.

Peripheral nerves have a unique structure and are designed to withstand certain types of mechanical stress and injury. They possess a protective layer, the epineurium, which helps safeguard the nerve fibers within from external damage. Additionally, peripheral nerves have a capacity for regeneration after injury, meaning that they can often recover function over time, unlike spinal cord grey matter, which is less capable of regeneration following injury and is more vulnerable to damage.

In contrast, spinal cord grey matter is crucial for processing and relaying signals to and from the brain and peripheral nervous system. It is composed of densely packed neuronal cell bodies and is more susceptible to ischemic injury, traumatic damage, and degenerative diseases. This susceptibility to injury is due to its cellular structure and the metabolic demands of the neurons in grey matter, making them more sensitive compared to their peripheral counterparts.

Given these differences, it's clear why peripheral nerves are classified as the least sensitive to injury when compared to spinal cord grey matter.