When it comes to Etomidate, which statement is accurate?

Etomidate is classified as a GABA agonist, meaning it enhances the action of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This increases the inhibitory effects within the central nervous system, leading to sedation and hypnosis, which is why Etomidate is commonly used for anesthesia induction. Its mechanism of action primarily revolves around modulation of GABA receptors rather than affecting NMDA receptors or decreasing muscle response amplitudes.

While it does not act as an NMDA antagonist, it does not enhance motor evoked potential (MEP) amplitude and does not increase latency in somatosensory evoked potentials (SSEPs). Understanding the pharmacological action of Etomidate is crucial for intraoperative monitoring, especially regarding patient safety and the interpretation of neurophysiological signals during surgery.